CIGE-19®
CIGE-19® is a granular extract obtained from Cistus Incanus, the plant with the highest percentage of polyphenols and flavonoids in Europe.
CIGE-19® has an extraordinary immunostimulant capacity, thanks to its incomparable analytical profile, especially rich in flavonoids like Quercetin.
CIGE-19® is a natural extract that activates the immune system effectively and safely, without adverse effects.
How CIGE-19® works?
The key to the mechanism of action of CIGE-19® lies in its high percentage in Quercetin-type Flavonoids and its ability to inhibit neuraminidase, a part of the outer cover of the virus, which allows its output and dispersion after multiplying inside our cells once infected, which is why it turns out to be a perfect target to limit the spread and infection capacity of the virus.
Mechanism of Action
Mediterranean NATURAL IMMUNITY
Cistus Incanus has the highest polyphenol content of any plant in Europe and has been widely studied during decades.
PROVEN EFFICACY
ANTIVIRAL
CIGE-19® exerts antiviral activity in cell culture without toxic side effects or the tendency to induce viral resistance1. CIGE-19® combines broad antiviral activity with low risk of virus resistance. Its mechanism of action involves blocking of primary virus attachment to cells by selective targeting of the viral envelope glycoproteins. In contrast, many other natural products with broad- spectrum antiviral activity target host cells components.
IMMUNOSTIMULANT
Thanks to its mechanism of defence, CIGE-19® is a natural and potent immunostimulant. CIGE-19®, as a Mediterranean plant, is challenged by multiple stressors, particularly during the summer, when water deficiency co- occurs with high solar irradiance and high temperatures. These environmental constraints induce severe photo-oxidative stress3, resulting in the formation of many reactive oxygen species (ROS). Within the plant cell, a first line of defence against reactive oxygen species is constituted by antioxidant enzymes.
Conclusions
CIGE-19® extract combines broad antiviral activity with low risk of virus resistance. Its mechanism of action involves blocking of primary virus attachment to cells by selective targeting of the viral envelope glycoproteins. In contrast, may other natural products with broad-spectrum antiviral activity target host cell components.
Our results demostrate that multiple antiviral components within the CIGE-19® extract block virus attachment to the host cell. Altogether, the broad and potent in vitro antiviral effects or CIGE-19® extract demonstrated in this study support the further exploration of CIGE-19® extract and its components for novel antiviral approaches.
FROM THE HEART OF THE MEDITERRANEAN
CIGE-19® is an Organic Biodynamic & Mediterranean certified product
OBM Certified
The properties of Organic Biodynamic and Mediterranean certified products are unique and impossible to achieve neither with chemical fertilizers nor with other sustainable farming methods
Full Traceability
CIGE19 traceability is 100% guaranteed and reflected in the CoA of each batch.
We carry out an exhaustive control of the entire production process
FROM THE SOIL TO THE EXTRACT
Each CIGE-19 batch is identified with unique QR that reflects the exact position where each Cistus Incanus has been grown, achieving a full traceability of the product through carbon footprint.
FROM THE HEART OF THE MEDITERRANEAN
CIGE-19® traceability is 100% guaranteed and
reflected in the CoA of each batch.
GMP SITE
CIGE-19® is produced in GMP certified facilities, guaranteeing our faithful adherence to good manufacturing practice guidelines. We use ancient sustainable growing traditions, combined with the most advanced manufacturing technologies. Facilities are also SFC certified guaranteeing total Safe Food Compliance.
